• Christina Cooley grew up in Conway, AR, where she studied Chemistry and Music at Hendrix College. Formative undergraduate research experiences in organic chemistry and neurobiology propelled her to a Ph.D. in Organic Chemistry at Stanford University, working in the laboratory of Professor Paul Wender to develop new oligomeric scaffolds for drug delivery applications. She then completed postdoctoral training in Chemical Biology at Scripps Research in San Diego with Professors Jeff Kelly and Luke Wiseman, focusing on therapeutic approaches for protein misfolding diseases. Christina joined the 性爱天堂 Chemistry faculty in 2015, where she leads an interdisciplinary undergraduate research program that applies the power of synthetic organic chemistry to impact related fields including polymer chemistry, medicinal chemistry and biology. Current major project areas include the development of fluorogenic radical polymerization reactions as platforms for biodetection, and prodrug strategies for disease-targeted therapeutic delivery. Beyond research, she is passionate about educating and mentoring the next generation of scientists, as well as serving the 性爱天堂 and broader scientific communities.

    • Postdoc in Chemical Biology, The Scripps Research Institute聽
    • Ph.D. in Organic Chemistry, Stanford University聽
    • B.A. in Chemistry, Hendrix College聽
    • Danyal Tahseen; Jemima R. Sackey-Addo; Zachary T. Allen; Joseph T. Anderson; Jordan B. McMurry; Christina B. Cooley. 鈥淔luorogenic Monomer Activation for Protein-Initiated Atom Transfer Radical Polymerization鈥 Org. Biomol. Chem. 2022, 20, 6257-6262.
    • Julia M. D. Grandjean; Aparajita Madhavan; Lauren Cech; Bryan O. Seguinot; Ryan J. Paxman; Emery Smith; Louis Scampavia; Evan T. Powers; Christina B. Cooley; Lars Plate; Timothy P. Spicer; Jeffery W. Kelly; R. Luke Wiseman. 鈥淧harmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming鈥 Nat. Chem. Biol. 2020, 16, 1052-1061.聽
    • Jonathan E. Palmer; Breanna M. Brietske; Tyler C. Bate; Erik A. Blackwood; Manasa Garg; Christopher C. Glembotski; Christina B. Cooley. 鈥淩eactive Oxygen Species (ROS)-Activatable Prodrug Strategy for Selective Activation of ATF6 Following Ischemia-Reperfusion Injury鈥 ACS Med. Chem. Lett. 2020, 11, 3, 292-297.聽
    • Zachary T. Allen;聽Jemima R. Sackey-Addo;聽Madeline P. Hopps;聽Danyal Tahseen;聽Joseph T. Anderson; Tyler A. Graf;聽Christina B. Cooley. 鈥淔luorogenic Atom Transfer Radical Polymerization in Aqueous Media as a Strategy for Detection鈥澛Chem. Sci.聽2019,听10,听1017-1022.
    • Lars Plate;*聽Christina B. Cooley;* John J. Chen; Ryan J. Paxman; Ciara M. Gallagher; Franck Madoux; Joseph C. Genereux; Wesley Dobbs; Dan Garza; Timothy P. Spicer; Louis Scampavia; Steven J. Brown; Hugh Rosen; Evan T. Powers; Peter Walter; Peter Hodder; R. Luke Wiseman; Jeffery W. Kelly. "Small Molecule Proteostasis Regulators that Reprogram the ER to Reduce Extracellular Protein Aggregation"聽eLIFE听2016,听5, e15550.聽
    • Christina B. Cooley;* Lisa M. Ryno;* Lars Plate; Gareth J. Morgan; John D. Hulleman; Jeffery W. Kelly; R. Luke Wiseman. 鈥淯nfolded Protein Response Activation Reduces Secretion and Extracellular Aggregation of Amyloidogenic Immunoglobulin Light Chain鈥澛Proc. Natl. Acad. Sci. USA聽2014,听111, 13046-13051.
    • Mathew D. Shoulders; Lisa M. Ryno;聽Christina B. Cooley; Jeffery W. Kelly; R. Luke Wiseman. 鈥淏roadly Applicable Methodology for the Rapid and Dosable Small Molecule-Mediated Regulation of Transcription Factors in Human Cells鈥澛J. Am. Chem. Soc.聽2013,听135, 8129-8132.
    • Erika I. Geihe;*聽Christina B. Cooley;* Justin Edward; Matthew K. Kiesewetter; Jeff Simon; James L. Hedrick; Robert M. Waymouth; Paul A. Wender. 鈥淒esigned Guanidinium-Rich Amphipathic Oligocarbonate Molecular Transporters Complex, Deliver and Release siRNA in Cells鈥澛Proc. Natl. Acad. Sci. USA聽2012,听109, 13171-13176.
    • Christina B. Cooley; Brian M. Trantow; Fredrik Nederberg; Matthew K. Kiesewetter; James L. Hedrick; Robert M. Waymouth; Paul A. Wender. 鈥淥ligocarbonate Molecular Transporters:聽 Oligomerization-Based Syntheses and Cell-Penetrating Studies鈥澛J. Am. Chem. Soc.聽2009,听131, 16401-16403.
    • Christina B. Cooley; Brian M. Trantow; Fredrik Nederberg; Matthew K. Kiesewetter; James L. Hedrick; Robert M. Waymouth; Paul A. Wender. 鈥淥ligocarbonate Molecular Transporters鈥 U.S. Patent 7,939,621,聽2011.

    *denotes equal authorship
    Underline denotes 性爱天堂 students or alumni

    • Fluorogenic Radical Polymerization
    • Biosensing
    • Monomer and Prodrug Synthesis
    • Targeted Drug Delivery

    The Cooley Lab has been supported by grants from federal agencies and private foundations including the National Science Foundation (CAREER and MRI programs), the Welch Foundation, the American Chemical Society Petroleum Research Fund, the Arnold and Mabel Beckman Foundation, and the San Antonio Area Foundation.

    • Organic Chemistry
    • Chemical Synthesis
    • Neurochemistry
    • Biochemistry Lab
    • 2021 National Science Foundation CAREER Award
    • 2021 性爱天堂 Early Career Award for Distinguished Research and Teaching
    • 2012 NIH NRSA Ruth L. Kirschstein Postdoctoral Fellowship
    • 2011 Stanford University Sessler Graduate Student Leadership Award
    • 2009 Stanford University Linus Pauling Teaching Award